Molecular Formula         C2H6O2S




is necessary for collagen synthesis: skin, hair, nails -- keeps cells from becoming rigid, softens tissue (the beauty mineral)

offers relief from stress, asthma, arthritis, inflammation, constipation,candida

detoxifies the body, increases blood circulation

reduces muscle cramps, leg cramps, back pain

removes inflammation, permits muscles to heal

increases energy, alertness, mental calmness, ability to concentrate

is a free radical scavenger -relieves allergies to foods and pollens

helps liver produce choline

controls acidity in stomach and ulcers

coats intestinal tract so parasites lose ability to hang on

helps with hypersensitivity to drugs

increases body's ability to produce insulin and is important for carbohydrate metabolism

speeds wound healing

is a food supplement/nutrient. No therapeutic claims are made or implied.






Sulfur plays an indispensable role in human nutrition which is often overlooked. It is responsible for the conformation of body proteins through the formation of disulfide bonds, thereby holding connective tissue together. Thiol (ie. sulfhydryl) groups are vital for the catalytic function of several body enzymes. To perform these roles, constant intake of assimilable sulphur is needed by the body.






Formor International  MSM is made with LIGNISUL MSM which comes from the industry's best purification process at a facility in the United States.

Your Body Demands Purity, You Demand LIGNISUL!

LIGNISUL MSM is the cleanest MSM available on the market, at a guaranteed 99.9% Purity level!

The Double Distilled MSM!

For the past ten years, LIGNISUL MSM has been produced with a Double Distillation process for unsurpassed quality! Many overseas manufacturers use a method of crystallization to make their MSM, which is generally regarded as a sub-par process compared to distillation. We use heat to separate our MSM from any impurity that may be present, which gives us the purest product on the market. Then we do it again. That's LIGNISUL MSM.

American Made for American Grade!

Manufactured in Alabama for over 30 years of experience in the manufacturing of top quality chemicals!  The plant is a member of SOCMA and a ChemStewards® company. We manufacture in compliance with GMP Guidelines and are ISO 9001:2000 certified. Rest assured, when you buy LIGNISUL you only get the best!




This short video will acquaint you with MSM so begin watching this presentation first.

MSM (Methyl-Sulfonyl-Methane)

MSM Guide.

MSM, methylsulfonylmethane (METH-el-sul-FON-il-METH-ane) provides sulfur, a vital building block of joints, cartilage, skin, hair and nails, and methyl groups, which support many vital biochemical processes in the body, including energy production. MSM is a naturally-occurring nutrient found in small amounts of many foods. As a dietary supplement, MSM is synthesized. When made correctly, it is identical to that found in nature. MSM can be taken alone or in combination with other joint health supplements, such as glucosamine and chondroitin.

Published, peer-reviewed clinical research in the U.S. has shown MSM is safe and effective in increasing joint comfort and supporting a normal range of motion.

How MSM Works to Improve Joint Health

MSM is thought to be effective in the fight against Osteoarthritis (OA) and other joint pain because of its high sulfur content, one of the building blocks of healthy joints.

What Causes Joint Pain?

Osteoarthritis (OA) and physical strain can lead to joint pain and swelling. MSM has been shown to relieve pain associated with OA. It has also shown anti-inflammatory effects in animal research.

Osteoarthritis (OA) is a nearly universal consequence of aging among vertebrates. Over 40 million Americans have some form of degenerative joint disease, including 80% of people over 50 years old. By the seventh decade, OA is nearly universal, producing the highest rate of morbidity of any disease.

Joints affected by OA suffer from uneven loading, which leads to altered lines of weight bearing. Cartilage (made by cells called chondrocytes) begins to build up to compensate for the uneven load, which forms roughening and deformities in the joint surface. The joints inflame and no longer operate smoothly, but instead the ball and socket rub unevenly from the friction of the outgrowths of cartilage and bone, called osteophytes. These changes cause irritation, triggering more cartilage growth and inflammation--  and the cycle of degeneration is set into motion. Science has been unsuccessful in finding a cure for OA, so instead, treatment focuses on easing the symptoms.

Sports injuries, tennis elbow, and tendonitis involve inflammation and micro-trauma to the soft tissues around the joints.

The inflammation caused by these injuries can easily become chronic due to overuse or improper after-care, resulting in symptoms not unlike arthritis: soreness, stiffness, and general pain in the region.

The Role of Sulfur in Joint Pain

MSM is thought to deliver sulfur to the body in a useable way. Sulfur helps maintain the structure of connective tissue by forming cross-linkages through disulfide bonds, i.e., sulfur strengthens the tissues that make up the joint.

Sulfur is critical to good joint health. Glycosaminoglycans (GAGs) are the fundamental building blocks of joint cartilage, and GAG molecules are linked together in chains by disulfide bonds. As the name implies, these bonds are between two sulfur atoms. The disulfide bridges reduce conformational flexibility of GAG chains, making cartilage firm and resilient. Cartilage integrity is thus a sulfur-dependent state.

MSM contains a lot of sulfur – 34% by weight. While more research is needed to determine how the body absorbs the sulfur it needs from MSM, preliminary studies in mice and in horses suggest that the sulfur in MSM is incorporated into proteins and into joint tissues.

Relieving Joint Pain with MSM

MSM Dosage

The generally recommended dosage is 1,500 to 6,000 mg of MSM per day. This is based on two double-blind studies of MSM for osteoarthritis of the knee.

Some people achieve results in as little as a week, but most research indicates that MSM may take more time to reduce joint problems.

For example, the 2006 Kim study period extended for 12 weeks, starting with a dose of 2 grams a day then increasing over the next three days to 6 grams per day.  In that study, pain was reduced by 25%, with the most dramatic change reported between week two and week four; pain continued to decrease all the way through week twelve, indicating that a longer study might have shown even further benefit.

MSM can be introduced to the joint in three ways, orally (liquid or pill), topically (a gel applied directly onto the joint), or by physician injection. Most experts recommend a mix of oral and topical application for best results. Injection should only be performed by qualified medical personnel.

Sport & Exercise Related Joint Pain & Injuries

MSM—Optimal Support for Athletic Performance and Recovery from Sports Injuries

MSM is a naturally occurring nutrient that provides the body with essential sulfur and methyl groups that are used in healing and repair processes. MSM is prized by professional and amateur athletes for effective nutritional support of athletic performance and recovery from soft tissue and joint injuries. MSM can safely be taken over the long term with no documented toxicity. As a result, athletes can achieve improved performance, pain relief, and enhanced tissue repair without fear of side effects.

Sulfur: The Key to Healthy Connective Tissue

Sports activities can build strength, endurance, and cardiovascular fitness. But they also increase the risk of minor injuries, and can cause wear-and-tear on joints, tendons, ligaments and other connective tissues. Athletes strive to improve their performance, but they also need to protect their bodies against injuries small and large. MSM can help.

Methyl Groups: Stoking the Fires of Metabolism

Many metabolic processes in the body—from the generation of energy to the synthesis of hormones—depend upon methyl groups. Methyl groups contain one carbon and three hydrogen atoms (CH3).  They are shuttled between various bio-molecules as a kind of regulatory currency. Nutrients that donate methyl groups (e.g., folic acid, vitamin B12, trimethylglycine, S-adenosylmethionine, MSM) can have wide ranging effects on health and longevity.

MSM for Sport Injuries

Every year, thousands of athletes suffer debilitating injuries or joint degeneration. Most sports injuries involve pain, redness, heat, and swelling: the four cardinal signs of inflammation. MSM supplementation can assist the healing process without the side effects typically associated with other products.

Treating an acute injury may be as simple as RICE. This acronym refers to rest, ice, compression, and elevation. For acute injuries, supplementation with MSM may also speed relief from inflammation and promote lasting healing.

After soft-tissue injuries, including the microtears in muscle that occur after typical strength training, connective tissue normally repairs itself. Sulfur is one of the key requirements for connective tissue integrity and repair. MSM provides a rich source of bioavailable sulfur to support connective tissue repair and regeneration.

MSM Safety

MSM is safe with no reported adverse effects, even at very large dosages.

Is MSM Safe?

Published scientific studies have shown MSM to be safe for human and animal use. Even at large dosage levels, there are no known significant adverse effects or drug interactions. Notably, these studies were conducted on highly purified forms of MSM; consumers should determine if the MSM they use has been appropriately processed to remove microscopic toxins or impurities.

How MSM is Manufactured

MSM occurs naturally in many common foods such as tomatoes and milk. However, its concentrations are so small that it is not feasible to commercially "extract it from nature." Commercial MSM of high purity is chemically identical to that found in nature.

All MSM is manufactured using a chemical synthesis process of reacting two raw materials, dimethyl sulfoxide  and hydrogen peroxide. This reaction forms a new molecule: MSM or dimethyl sulfone. After reaction, a purification process is needed to remove any impurities from the MSM.  Two commonly accepted purification processes used in most chemical and food processing plants are distillation and crystallization.  Distillation is the favored process for producing high purity MSM, where heat is used to separate compounds by their unique boiling points.  MSM has a boiling point of 478ºF. The distillation of MSM results in a very pure product.  Conversely, purification by crystallization can be adversely affected by the use of impure solvents, potentially leaving undesirable or toxic by-products.

If MSM is not manufactured properly, or is produced in a facility that makes multiple products with improper sanitation procedures, contamination is likely. There may also be a chance that impurities (such as heavy metals or chlorinated hydrocarbons) from the water used in the synthesis and crystallization process will remain in the final product.

Other factors that determine the purity of synthesized MSM is consistent product formulation and strict process control procedures. A good MSM manufacturer uses in-process control and rigorous product testing to ensure the product is indeed pure.

The nutrition industry has established standards for testing MSM material so that all manufacturers use the same types of procedures and instruments for testing. These standards are developed by AOAC International, an independent, NIH-sponsored, FDA-endorsed international community of analytical chemists. Industry guidelines recommend that raw material and finished products manufacturers use these accepted methods to ensure consistent quality. These methods establish "a gold standard" by which all products can be uniformly measured.

MSM and Allergies - MSM Side Effects

There have been no reported cases of allergic reactions to MSM in the medical literature, though there are a handful of unpublished anecdotes of minor side effects like loose stools, stomach upset or skin rashes, conditions which disappeared immediately after stopping the supplementation.

Dr. Stanley Jacob M.D. of the Oregon Health & Science University reports treating over 18,000 patients in his medical practice, some of whom where given very high dosages, without adverse effects.

The toxicology of MSM has been explored in several studies:

DMSO vs MSM — Which Should You Choose? 


Sulphur is an important element in the human body, and is vital to our health and well-being. 

DMSO and MSM are both sulfur compounds. DMSO is the “shortened form” of Dimethyl SulfoxideMSM stands for Methyl-sulfonyl-methane.  


Considerable research on DMSO was carried out by Dr Stanley Jacob (Oregon Health Sciences University) in the early 1960’s. 

In his writings, Dr. Jacob refers to many studies and scientific papers relating to the health benefits of DMSO. DMSO is linked to numerous beneficial effects, including relief of muscle and joint pain, reduced inflammation, healing of skin ulcers, and a long list of other benefits.

DMSO has been somewhat controversial over the years, however. In the USA, it is available only on prescription, as the FDA had concerns in the mid-1960’s over some alleged side-effects. DMSO cannot be sold legally to the general public for health purposes.

DMSO itself is a powerful solvent. It is a versatile compound, and can be found in paint thinners and antifreeze. There is some concern that “industrial grade” DMSO, used by factories, is being purchased by individuals seeking the health benefits of DMSO. Industrial grade DMSO is about 99% pure, but is not approved for “medical” purposes. It is the only “legal” way that DMSO can be obtained by individual consumers. 

Outside of the USA, DMSO is approved in a number of countries for its medicinal benefits. DMSO is a strong smelling compound. One of its less pleasant side-effects is that users tend to smell of garlic or oysters! Other reported side effects are itching skin, nasal congestion, shortness of breath, excess intestinal gas, nausea, and headaches, though these are not necessarily common.

None of these side effects are especially hazardous, but can be very annoying or uncomfortable.  Particular caution must be taken with DMSO, however, because of its very powerful effect as a solvent: it can transport almost anything through the skin or cellular membranes.  This means that it can transport germs and bacteria through the user’s skin; any impurities in the DMSO would be carried into the body’s cells.


In practice, a significant proportion of DMSO is converted into MSM when ingested in the human body. MSM is believed to have many of the health benefits of DMSO, but can be sold directly to consumers. 

It has no known side effects, even when consumed in significant quantities. Many people believe it provides the body with a superior source of sulfur, more easily assimilated.

As DMSO can generally be sold only as a solvent, it does not have to meet the health and safety requirements of MSM. There is a risk that it could be sold with chemical impurities in it, rendering it dangerous. 

DMSO is considered to be a drug, and is only available in many countries by prescription. 

MSM is an excellent source of dietary sulfur, and can be considered to be a food supplement. It is reputed to have very similar effects to DMSO, without the alleged side effects.  Dr Stanley Jacobs has authored a best-selling book on the many benefits of MSM, The Miracle of MSM

Below is a table for easy reference, showing some of the key differences:

MSM vs DMSO    
Naturally occurring in the human body?


Is easy to purchase & legal?



Side effects?



Is used by many people to help arthritis, fibromyalgia, muscle & joint pains, asthma, M.S., burns, scar tissue?



Bob Fox

Robert S. Fox