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The human brain is the center of the human nervous system and is a highly complex organ. Enclosed in the cranium, it has the same general structure as the brains of other mammals, but is over three times as large as the brain of a typical mammal with an equivalent body size.^[1] Most of the expansion comes from the cerebral cortex, a convoluted layer of neural tissue that covers the surface of the forebrain. Especially expanded are the frontal lobes, which are involved in executive functions such as self-control, planning, reasoning, and abstract thought. The portion of the brain devoted to vision is also greatly enlarged in human beings.

Brain evolution, from the earliest shrewlike mammals through primates to hominids, is marked by a steady increase in encephalization, or the ratio of brain to body size. The human brain has been estimated to contain 50–100 billion (10¹¹) neurons, of which about 10 billion (10¹⁰) are cortical pyramidal cells. These cells pass signals to each other via as many as 1000 trillion (10¹⁵) synaptic connections ^[2].

The brain monitors and regulates the body's actions and reactions. It continuously receives sensory information, and rapidly analyzes this data and then responds, controlling bodily actions and functions. The brainstem controls breathing, heart rate, and other autonomic processes. The neocortex is the center of higher-order thinking, learning, and memory. The cerebellum is responsible for the body's balance, posture, and the coordination of movement.

In spite of the fact that it is protected by the thick bones of the skull, suspended in cerebrospinal fluid, and isolated from the bloodstream by the blood-brain barrier, the delicate nature of the human brain makes it susceptible to many types of damage and disease. The most common forms of physical damage are closed head injuries such as a blow to the head, a stroke, or poisoning by a wide variety of chemicals that can act as neurotoxins. Infection of the brain is rare because of the barriers that protect it, but is very serious when it occurs. More common are genetically based diseases^{[citation needed]}, such as Parkinson's disease, multiple sclerosis, and many others. A number of psychiatric conditions, such as schizophrenia and depression, are widely thought to be caused at least partially by brain dysfunctions, although the nature of such brain anomalies is not well understood.

Contents [hide] 1 Structure 1.1 Topography 1.2 Lateralization 2 Sources of information 2.1 EEG 2.2 MEG 2.3 Structural and functional imaging 2.4 Effects of brain damage 3 Language 4 Pathology 5 See also 6 Notes 7 References 8 External links

[edit] Structure

The adult human brain weighs on average about 3 lb (1.5 kg)^[3] with a size of around 1130 cubic centimetres (cm³) in women and 1260 cm³ in men, although there is substantial individual variation.^[4] Men's brains are on average 100g heavier than a woman's, even when corrected for body size differences^[5] The brain is very soft, having a consistency similar to soft gelatin or firm tofu. Despite being referred to as "grey matter", the live cortex is pinkish-beige in color and slightly off-white in the interior. The photo on the right shows a horizontal slice of the head of an adult man, from the National Library of Medicine's Visible Human Project. In this project, two human cadavers (from a man and a woman) were frozen and then sliced into thin sections, which were individually photographed and digitized. The slice here is taken from a small distance below the top of the brain, and shows the cerebral cortex (the convoluted cellular layer on the outside) and the underlying white matter, which consists of myelinated fiber tracts traveling to and from the cerebral cortex. At the age of 20, a man has around 176,000 km and a woman, about 149,000 km of myelinated axons in their brains.^[6]

The cerebral hemispheres form the largest part of the human brain and are situated above most other brain structures. They are covered with a cortical layer with a convoluted topography.^[7] Underneath the cerebrum lies the brainstem, resembling a stalk on which the cerebrum is attached. At the rear of the brain, beneath the cerebrum and behind the brainstem, is the cerebellum, a structure with a horizontally furrowed surface that makes it look different from any other brain area. The same structures are present in other mammals, although the cerebellum is not so large relative to the rest of the brain. As a rule, the smaller the cerebrum, the less convoluted the cortex. The cortex of a rat or mouse is almost completely smooth. The cortex of a dolphin or whale, on the other hand, is more convoluted than the cortex of a human.

The dominant feature of the human brain is corticalization. The cerebral cortex in humans is so large that it overshadows every other part of the brain. A few subcortical structures show alterations reflecting this trend. The cerebellum, for example, has a medial zone connected mainly to subcortical motor areas, and a lateral zone connected primarily to the cortex. In humans the lateral zone takes up a much larger fraction of the cerebellum than in most other mammalian species. Corticalization is reflected in function as well as structure. In a rat, surgical removal of the entire cerebral cortex leaves an animal that is still capable of walking around and interacting with the environment.^[8] In a human, comparable cerebral cortex damage produces a permanent state of coma.

The cerebral cortex is nearly symmetric in outward form, with left and right hemispheres. Anatomists conventionally divide each hemisphere into four "lobes", the frontal lobe, parietal lobe, temporal lobe, and occipital lobe. It is important to realize that this categorization does not actually arise from the structure of the cortex itself: the lobes are named after the bones of the skull that overlie them. There is one exception: the border between the frontal and parietal lobes is shifted backward to the central sulcus, a deep fold that marks the line where the primary somatosensory cortex and primary motor cortex come together.

Researchers who study the functions of the cortex divide it into three functional categories of regions, or areas. One consists of the primary sensory areas, which receive signals from the sensory nerves and tracts by way of relay nuclei in the thalamus. Primary sensory areas include the visual area of the occipital lobe, the auditory area in the temporal lobe, and the somatosensory area in the parietal lobe. A second category is the primary motor area, which sends axons down to motor neurons in the brainstem and spinal chord. This area occupies the rear portion of the frontal lobe, directly in front of the somatosensory area. The third category consists of the remaining parts of the cortex, which are called the association areas. These areas receive input from the sensory areas and lower parts of the brain and are involved in the complex process that we call perception, thought, and decision making. The amount of association cortex, relative to the other two categories, increase dramatically as one goes from simpler mammals, such as the rat and the cat, to more complex ones, such as the chimpanzee and the human. ^[9]

The cerebral cortex is essentially a sheet of neural tissue, folded in a way that allows a large surface area to fit within the confines of the skull. Each cerebral hemisphere, in fact, has a total surface area of about 1.3 square feet.^[10] Anatomists call each cortical fold a sulcus, and the smooth area between folds a gyrus. Most human brains show a similar pattern of folding, but there are enough variations in the shape and placement of folds to make every brain unique. Nevertheless, the pattern is consistent enough for each major fold to have a name, for example, the "superior frontal gyrus", "postcentral sulcus", or "trans-occipital sulcus". Deep folding features in brain such as the inter-hemispheric and lateral fissure, and the insular cortex are present in almost all normal subjects.

Different parts of the cerebral cortex are involved in different cognitive and behavioral functions. The differences show up in a number of ways: the effects of localized brain damage, regional activity patterns exposed when the brain is examined using functional imaging techniques, connectivity with subcortical areas, and regional differences in the cellular architecture of the cortex. Anatomists describe most of the cortex—the part they call isocortex—as having six layers, but not all layers are apparent in all areas, and even when a layer is present, its thickness and cellular organization may vary. Several anatomists have constructed maps of cortical areas on the basis of variations in the appearance of the layers as seen with a microscope. One of the most widely used schemes came from Brodmann, who split the cortex into 51 different areas and assigned each a number (anatomists have since subdivided many of the Brodmann areas^{[citation needed]}). For example, Brodmann area 1 is the primary somatosensory cortex, Brodmann area 17 is the primary visual cortex, and Brodmann area 25 is the anterior cingulate cortex.

[edit] Topography

Many of the brain areas Brodmann defined have their own complex internal structures. In a number of cases, brain areas are organized into "topographic maps", where adjoining bits of the cortex correspond to adjoining parts of the body, or of some more abstract entity. A simple example of this type of correspondence is the primary motor cortex, a strip of tissue running along the anterior edge of the central sulcus, shown in the image to the right. Motor areas innervating each part of the body arise from a distinct zone, with neighboring body parts represented by neighboring zones. Electrical stimulation of the cortex at any point causes a muscle-contraction in the represented body part. This "somatotopic" representation is not evenly distributed, however. The head, for example, is represented by a region about three times as large as the zone for the entire back and trunk. The size of a zone correlates to the precision of motor control and sensory discrimination possible^{[citation needed]}. The areas for the lips, fingers, and tongue are particularly large, considering the proportional size of their represented body parts.

In visual areas, the maps are retinotopic—that is, they reflect the topography of the retina, the layer of light-activated neurons lining the back of the eye. In this case too the representation is uneven: the fovea—the area at the center of the visual field—is greatly overrepresented compared to the periphery. The visual circuitry in the human cerebral cortex contains several dozen distinct retinotopic maps, each devoted to analyzing the visual input stream in a particular way^{[citation needed]}. The primary visual cortex (Brodmann area 17), which is the main recipient of direct input from the visual part of the thalamus, contains many neurons that are most easily activated by edges with a particular orientation moving across a particular point in the visual field. Visual areas farther downstream extract features such as color, motion, and shape.

In auditory areas, the primary map is tonotopic. Sounds are parsed according to frequency (i.e., high pitch vs. low pitch) by subcortical auditory areas, and this parsing is reflected by the primary auditory zone of the cortex. As with the visual system, there are a number of tonotopic cortical maps, each devoted to analyzing sound in a particular way.

Within a topographic map there can sometimes be finer levels of spatial structure. In the primary visual cortex, for example, where the main organization is retinotopic and the main responses are to moving edges, cells that respond to different edge-orientations are spatially segregated from one another^{[citation needed]}.

[edit] Lateralization

Each hemisphere of the brain interacts primarily with one half of the body, but for reasons that are unclear, the connections are crossed: the left side of the brain interacts with the right side of the body, and vice versa. Motor connections from the brain to the spinal cord, and sensory connections from the spinal cord to the brain, both cross the midline at brainstem levels. Visual input follows a more complex rule: the optic nerves from the two eyes come together at a point called the optic chiasm, and half of the fibers from each nerve split off to join the other. The result is that connections from the left half of the retina, in both eyes, go to the left side of the brain, whereas connections from the right half of the retina go to the right side of the brain. Because each half of the retina receives light coming from the opposite half of the visual field, the functional consequence is that visual input from the left side of the world goes to the right side of the brain, and vice versa. Thus, the right side of the brain receives somatosensory input from the left side of the body, and visual input from the left side of the visual field—an arrangement that presumably is helpful for visuomotor coordination.

The two cerebral hemispheres are connected by a very large nerve bundle called the corpus callosum, which crosses the midline above the level of the thalamus. There are also two much smaller connections, the anterior commisure and hippocampal commisure, as well as many subcortical connections that cross the midline. The corpus callosum is the main avenue of communication between the two hemispheres, though. It connects each point on the cortex to the mirror-image point in the opposite hemisphere, and also connects to functionally related points in different cortical areas.

In most respects, the left and right sides of the brain are symmetrical in terms of function. For example, the counterpart of the left-hemisphere motor area controlling the right hand is the right-hemisphere area controlling the left hand. There are, however, several very important exceptions, involving language and spatial cognition. In most people, the left hemisphere is "dominant" for language: a stroke that damages a key language area in the left hemisphere can leave the victim unable to speak or understand, whereas equivalent damage to the right hemisphere would cause only minor impairment to language skills.

A substantial part of our current understanding of the interactions between the two hemispheres has come from the study of "split-brain patients"—people who underwent surgical transection of the corpus callosum in an attempt to reduce the severity of epileptic seizures. These patients do not show unusual behavior that is immediately obvious, but in some cases can behave almost like two different people in the same body, with the right hand taking an action and then the left hand undoing it. Most such patients, when briefly shown a picture on the right side of the point of visual fixation, are able to describe it verbally, but when the picture is shown on the left, are unable to describe it, but may be able to give an indication with the left hand of the nature of the object shown.

It should be noted that the differences between left and right hemispheres are greatly overblown in much of the popular literature on this topic. The existence of differences has been solidly established, but many popular books go far beyond the evidence in attributing features of personality or intelligence to the left or right hemisphere dominance.^{[citation needed]}

[edit] Sources of information

Information about the structure and function of the human brain comes from a variety of sources. Most information about the cellular components of the brain and how they work comes from studies of animal subjects, using techniques described in the brain article. Some techniques, however, are used mainly in humans, and therefore are described here.

[edit] EEG

By placing electrodes on the scalp it is possible to record the summed electrical activity of the cortex, in a technique known as electroencephalography (EEG).^[11] EEG measures mass changes in population synaptic activity from the cerebral cortex, but can only detect changes over large areas of the brain, with very little sensitivity for sub-cortical activity. EEG recordings can detect events lasting only a few thousandths of a second. EEG recordings have good temporal resolution, but poor spatial resolution.

[edit] MEG

Apart from measuring the electric field around the skull it is possible to measure the magnetic field directly in a technique known as magnetoencephalography (MEG).^[12] This technique has the same temporal resolution as EEG but much better spatial resolution, although not as good as fMRI. The greatest disadvantage of MEG is that, because the magnetic fields generated by neural activity are very weak, the method is only capable of picking up signals from near the surface of the cortex, and even then, only neurons located in the depths of cortical folds (sulci) have dendrites oriented in a way that gives rise to detectable magnetic fields outside the skull.

[edit] Structural and functional imaging

There are several methods for detecting brain activity changes by three-dimensional imaging of local changes in blood flow. The older methods are SPECT and PET, which depend on injection of radioactive tracers into the bloodstream. The newest method, functional magnetic resonance imaging (fMRI), has considerably better spatial resolution and involves no radioactivity.^[13] Using the most powerful magnets currently available, fMRI can localize brain activity changes to regions as small as one cubic millimeter. The downside is that the temporal resolution is poor: when brain activity increases, the blood flow response is delayed by 1–5 seconds and lasts for at least 10 seconds. Thus, fMRI is a very useful tool for learning which brain regions are involved in a given behavior, but gives little information about the temporal dynamics of their responses. A major advantage for fMRI is that, because it is non-invasive, it can readily be used on human subjects.

[edit] Effects of brain damage

A key source of information about the function of brain regions is the effects of damage to them.^[14] In humans, strokes have long provided a "natural laboratory" for studying the effects of brain damage. Most strokes result from a blood clot lodging in the brain and blocking the local blood supply, causing damage or destruction of nearby brain tissue: the range of possible blockages is very wide, leading to a great diversity of stroke symptoms. Analysis of strokes is limited by the fact that damage often crosses into multiple regions of the brain, not along clear-cut borders, making it difficult to draw firm conclusions.

[edit] Language

In human beings, it is the left hemisphere that usually contains the specialized language areas. While this holds true for 97% of right-handed people, about 19% of left-handed people have their language areas in the right hemisphere and as many as 68% of them have some language abilities in both the left and the right hemisphere. The two hemispheres are thought to contribute to the processing and understanding of language: the left hemisphere processes the linguistic meaning of prosody (or, the rhythm, stress, and intonation of connected speech), while the right hemisphere processes the emotions conveyed by prosody.^[15] Studies of children have shown that if a child has damage to the left hemisphere, the child may develop language in the right hemisphere instead. The younger the child, the better the recovery. So, although the "natural" tendency is for language to develop on the left, human brains are capable of adapting to difficult circumstances, if the damage occurs early enough.

The first language area within the left hemisphere to be discovered is Broca's area, named after Paul Broca, who discovered the area while studying patients with aphasia, a language disorder. Broca's area doesn't just handle getting language out in a motor sense, though. It seems to be more generally involved in the ability to process grammar itself, at least the more complex aspects of grammar. For example, it handles distinguishing a sentence in passive form from a simpler subject-verb-object sentence — the difference between "The boy was hit by the girl" and "The girl hit the boy."

The second language area to be discovered is called Wernicke's area, after Carl Wernicke, a German neurologist who discovered the area while studying patients who had similar symptoms to Broca's area patients but damage to a different part of their brain. Wernicke's aphasia is the term for the disorder occurring upon damage to a patient's Wernicke's area.

Wernicke's aphasia does not only affect speech comprehension. People with Wernicke's aphasia also have difficulty recalling the names of objects, often responding with words that sound similar, or the names of related things, as if they are having a hard time recalling word associations^{[citation needed]}.

[edit] Pathology

Clinically, death is defined as an absence of brain activity as measured by EEG. Injuries to the brain tend to affect large areas of the organ, sometimes causing major deficits in intelligence, memory, personality, and movement. Head trauma caused, for example, by vehicle or industrial accidents, is a leading cause of death in youth and middle age. In many cases, more damage is caused by resultant edema than by the impact itself. Stroke, caused by the blockage or rupturing of blood vessels in the brain, is another major cause of death from brain damage.

Other problems in the brain can be more accurately classified as diseases than as injuries. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, motor neurone disease, and Huntington's disease are caused by the gradual death of individual neurons, leading to diminution in movement control, memory, and cognition.

Mental disorders, such as clinical depression, schizophrenia, bipolar disorder and post-traumatic stress disorder may involve particular patterns of neuropsychological functioning related to various aspects of mental and somatic function. These disorders may be treated by psychotherapy, psychiatric medication or social intervention and personal recovery work; the underlying issues and associated prognosis vary significantly between individuals.

Some infectious diseases affecting the brain are caused by viruses and bacteria. Infection of the meninges, the membrane that covers the brain, can lead to meningitis. Bovine spongiform encephalopathy (also known as "mad cow disease") is deadly in cattle and humans and is linked to prions. Kuru is a similar prion-borne degenerative brain disease affecting humans. Both are linked to the ingestion of neural tissue, and may explain the tendency in human and some non-human species to avoid cannibalism. Viral or bacterial causes have been reported in multiple sclerosis and Parkinson's disease, and are established causes of encephalopathy, and encephalomyelitis.

Many brain disorders are congenital, occurring during development. Tay-Sachs disease, Fragile X syndrome, and Down syndrome are all linked to genetic and chromosomal errors. Many other syndromes, such as the intrinsic circadian rhythm disorders, are suspected to be congenital as well. Normal development of the brain can be altered by genetic factors, drug use, nutritional deficiencies, and infectious diseases during pregnancy.

Certain brain disorders are treated by neurosurgeons, while others are treated by neurologists and psychiatrists.

[edit] See also

• Cephalic disorders, concerning defects of the head, especially the brain
• History of the brain
• Lateralization of brain function
• Lobes of the brain
• Neuroanatomy
• Neuroanthropology
• Neuroscience
• Regions in the human brain
• Common misconceptions about the brain
• Decade of the Brain

[edit] Notes

[edit] References

[edit] External links

• The Brain from Top to Bottom
• The Whole Brain Atlas
• High-Resolution Cytoarchitectural Primate Brain Atlases
• Brain Facts and Figures
• Current Research Regarding the Human Brain ScienceDaily
• Estimating the computational capabilities of the human brain
• When will computer hardware match the human brain? – an article by Hans Moravec
• How the human brain works
• Everything you wanted to know about the human brain — Provided by New Scientist.
• Differences between female & male human brains
• Surface Anatomy of the Brain
• Scientific American Magazine (May 2005 Issue) His Brain, Her Brain About differences between female and male brains.

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[show] v • d • e Neuropsychology   Topics Brain-computer interface · Traumatic brain injury · Brain regions · Clinical neuropsychology · Cognitive neuroscience · Human brain · Neuroanatomy · Neurophysiology · Phrenology · Misconceptions   Brain functions Arousal · Attention · Consciousness · Decision making · Executive functions · Natural language · Learning · Memory · Motor coordination · Sensory perception · Planning · Problem solving · Thought   People Arthur L. Benton · David Bohm · António Damásio · Phineas Gage · Norman Geschwind · Elkhonon Goldberg · Donald O. Hebb · Kenneth Heilman · Edith Kaplan · Muriel Lezak · Benjamin Libet · Rodolfo Llinás · Alexander Luria · Brenda Milner · Karl H. Pribram · Oliver Sacks · Roger W. Sperry · H. M. · K. C.   Tests Bender-Gestalt Test · Benton Visual Retention Test · Clinical Dementia Rating · Continuous Performance Task · Glasgow Coma Scale · Hayling and Brixton tests · Johari window · Lexical decision task · Mini-mental state examination · Stroop effect · Wechsler Adult Intelligence Scale · Wisconsin card sorting   Mind and Brain Portal

[show] v • d • e Nervous system (TA A14, GA 9)   Central nervous system Meninges Spinal cord Brain: Rhombencephalon (Medulla oblongata, Pons, Cerebellum) • Mesencephalon • Prosencephalon (Diencephalon, Telencephalon)   Peripheral nervous system   Somatic Sensory nerve • Motor nerve • Cranial nerves • Spinal nerves   Autonomic Sympathetic • Parasympathetic • Enteric nervous system   central nervous system navs: anat/physio/dev, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc peripheral nervous system navs: anat/histo/physio/dev, noncongen PNS somatic/autonomic/congen/neoplasia, symptoms+signs/eponymous, proc

[show] v • d • e Human brain: rhombencephalon, myelencephalon: medulla (TA A14.1.04, GA 9.767)   Dorsal   Surface Posterior median sulcus · Posterolateral sulcus · Area postrema · Vagal trigone · Hypoglossal trigone · Medial eminence   Grey: Cranial nuclei afferent: GVA: VII,IX,X: Solitary/tract/Dorsal respiratory group · SVA: Gustatory nucleus · GSA: VIII-v (Lateral, Medial, Inferior)   efferent: GSE: XII  · GVE: IX,X,XI: Ambiguus · SVE: X: Dorsal · IX: Inferior salivatory nucleus   Grey: other Gracile nucleus · Cuneate nucleus · Accessory cuneate nucleus   White: Sensory/ascending Sensory decussation  · Medial lemniscus · Inferior cerebellar peduncle (Juxtarestiform body) · Ascending dorsal longitudinal fasciculus · MLF, III, IV and VI   White: Motor/descending Descending dorsal longitudinal fasciculus · MLF, III, IV and VI   Ventral   White: Motor/descending Motor decussation · Olivocerebellar tract · Rubro-olivary tract   Grey matter Ventral respiratory group · Arcuate nucleus of medulla · Inferior olivary nucleus   Surface Anterior median fissure · Antero-lateral sulcus · Olive · Pyramid   Grey: Raphe/ reticular Reticular formation (Gigantocellular, Parvocellular, Ventral, Lateral, Paramedian) · Raphe nuclei (Obscurus, Magnus, Pallidus)

[show] v • d • e Human brain, rhombencephalon, metencephalon: pons (TA A14.1.05.101-604, GA 9.785)   Dorsal/ (tegmentum)   Surface Cerebellopontine angle · Superior medullary velum · Sulcus limitans · Medial eminence · Facial colliculus   White: Sensory/ascending Trapezoid body/VIII · Trigeminal lemniscus (Dorsal trigeminal tract, Ventral trigeminal tract) · Medial lemniscus · Lateral lemniscus   MLF, III, IV and VI: Vestibulo-oculomotor fibers Anterior trigeminothalamic tract · Central tegmental tract   White: Motor/descending ICP (Vestibulocerebellar tract)   MLF, III, IV and VI: Vestibulospinal tract (Medial vestibulospinal tract, Lateral vestibulospinal tract)   Grey: Cranial nuclei afferent: GSA: Principal V/Spinal V · VIII-c (Dorsal, Anterior)/VIII-v (Superior)   efferent: SVE: Motor V  · VII · GSE: VI · GVE: VII: Superior salivary nucleus   Other grey Apneustic center · Pneumotaxic center (Medial parabrachial nucleus) · Lateral parabrachial nucleus · Superior olivary nucleus · Caerulean nucleus   Ventral/ (base)   Grey Pontine nuclei   White: Motor/descending Corticospinal tract · Corticobulbar tract · Corticopontine fibers   MCP (Pontocerebellar fibers)   Surface Basilar sulcus   Other grey: Raphe/ reticular Reticular formation (Caudal, Oral, Tegmental, Paramedian) · Raphe nuclei (Median)

[show] v • d • e Human brain: mesencephalon (midbrain) (TA A14.1.06, GA 9.800)   Tectum (Dorsal)   Surface Corpora quadrigemina: Inferior colliculi (Brachium of inferior colliculus), Superior colliculi (Brachium of superior colliculus)   Grey matter Pretectal area   White: Sensory/ascending Spinotectal tract · Central tegmental tract   White: Motor/descending Tectospinal tract   Peduncle (Ventral)   Peduncle tegmentum   White: Sensory/ascending lemnisci (Medial, Lateral) · Ascending MLF (Vestibulo-oculomotor fibers) · Spinothalamic tract · Anterior trigeminothalamic tract · Dentatothalamic tract   White: Motor/descending Rubrospinal tract · Rubro-olivary tract · Descending MLF   Grey: cranial nuclei GSA (V: Mesencephalic) - GSE (III: Oculomotor, IV: Trochlear) - GVE (III: Edinger-Westphal)   Grey: other Periaqueductal gray/Raphe nuclei (Dorsal raphe nucleus) Ventral tegmental area • Pedunculopontine nucleus • Red nucleus riMLF   Ventricular system Cerebral aqueduct   Peduncle base   White: Motor/descending Cerebral crus: Corticospinal tract · Corticobulbar tract · Corticopontine tract/Frontopontine fibers/Temporopontine fibers   Grey: Substantia nigra Pars compacta · Pars reticulata   Surface Superior cerebellar peduncle (Decussation of superior cerebellar peduncles) · Interpeduncular fossa

[show] v • d • e Human brain, rhombencephalon, metencephalon: cerebellum (TA 14.1.07, GA 9.788)   Surface anatomy   Lobes Anterior lobe · Posterior lobe (Horizontal fissure) · Flocculonodular lobe (Flocculus, Nodule)   Primary fissure   Medial/lateral Vermis: anterior (Central lobule, Culmen, Lingula) · posterior (Folium, Tuber, Uvula) · Vallecula of cerebellum   Hemisphere: anterior (Alar central lobule) · posterior (Biventer lobule, Cerebellar tonsil)   Grey matter   Deep cerebellar nuclei Dentate · interposed (Emboliform, Globose) · Fastigial   Cerebellar cortex Molecular layer (Stellate cell, Basket cell) Purkinje cell layer (Purkinje cell, Bergmann glia cell = Golgi epithelial cell) Granule cell layer (Golgi cell, Granule cell, Unipolar brush cell) Fibers: Mossy fibers · Climbing fiber · Parallel fiber   White matter   Internal Arbor vitae   Peduncles Inferior (medulla): Dorsal spinocerebellar tract · Olivocerebellar tract · Cuneocerebellar tract · Juxtarestiform body (Vestibulocerebellar tract) Middle (pons): Pontocerebellar fibers Superior (midbrain): Ventral spinocerebellar tract · Dentatothalamic tract · Trigeminocerebellar fibers

[show] v • d • e Human brain: diencephalon (TA A14.1.08, GA 9.807)   Epithalamus   Surface Pineal body · Habenula · Habenular trigone · Habenular commissure   Grey matter Pretectal area · Habenular nuclei · Subcommissural organ   Thalamus   Surface Stria medullaris of thalamus · Thalamic reticular nucleus · Taenia thalami   Grey matter/ nuclei paired: AN · Ventral (VA/VL, VP/VPM/VPL) · Lateral (LD, LP, Pulvinar) · Metathalamus (MG, LG)   midline: MD · Intralaminar (Centromedian) · Midline nuclear group · Interthalamic adhesion   White matter Mammillothalamic fasciculus · Pallidothalamic tracts (Ansa lenticularis, Lenticular fasciculus, Thalamic fasciculus) · PCML (Medial lemniscus, Trigeminal lemniscus) · Spinothalamic tract · Lateral lemniscus · Dentatothalamic tract · Acoustic radiation · Optic radiation · Subthalamic fasciculus · Anterior trigeminothalamic tract   Medullary laminae   Hypothalamus   Surface Median eminence/Tuber cinereum · Mammillary body · Infundibulum   Grey matter   Autonomic zones Anterior (parasympathetic/heat loss) · Posterior (sympathetic/heat conservation)   Endocrine posterior pituitary: magnocellular/Paraventricular/Supraoptic (oxytocin/vasopressin)   other: parvocellular/Arcuate (dopamine/GHRH) · Preoptic (GnRH) · Suprachiasmatic (melatonin)   Emotion Lateral (hunger) · Ventromedial (satiety) · Dorsomedial (rage)   White matter afferent (SN → Medial forebrain bundle) · efferent (Mammillothalamic fasciculus → AN, Stria terminalis → Amygdala, Dorsal longitudinal fasciculus → SC)   Pituitary Posterior is diencephalon, but anterior is glandular   Subthalamus Subthalamic nucleus · Zona incerta   Ventricular system: Third ventricle recesses: (Optic recess, Infundibular recess, Suprapineal recess, Pineal recess) Hypothalamic sulcus · Tela chorioidea of third ventricle Subfornical organ Apertures: Interventricular/Monro Posterior commissure

[show] v • d • e Human brain: forebrain (cerebrum · cerebral cortex · cerebral hemispheres, grey matter) (TA A14.1.09.002-240, 301-320, GA 9.818-826)   Frontal lobe   Superolateral   Prefrontal Superior frontal gyrus (4l, 6l, 8l) · Middle frontal gyrus (9l, 10l, 46) Inferior frontal gyrus: 11l · 47-Pars orbitalis · Broca's area (44-Pars opercularis, 45-Pars triangularis) Superior frontal sulcus · Inferior frontal sulcus   Precentral Precentral gyrus · Precentral sulcus   Medial/inferior   Prefrontal Superior frontal gyrus (4m, 6m) · Medial frontal gyrus (8m, 9m) Paraterminal gyrus/Paraolfactory area (12) · Straight gyrus (11m) · Orbital gyri/Orbitofrontal cortex (10m, 11m, 12) · Ventromedial prefrontal cortex (10m) · Subcallosal area (25) Olfactory sulcus · Orbital sulci   Precentral Paracentral lobule (4) · Paracentral sulcus   Both Primary motor cortex (4) · Premotor cortex (6) · Supplementary motor area (6) · Frontal eye fields (8)   Parietal lobe   Superolateral Superior parietal lobule (5l, 7l) · Inferior parietal lobule (40-Supramarginal gyrus, 39-Angular gyrus) · Parietal operculum (43) Intraparietal sulcus   Medial/inferior Paracentral lobule (1m, 2m, 3m, 5m) · Precuneus (7m)   Marginal sulcus   Both Postcentral gyrus/primary somatosensory cortex (1 · 2 · 3) · Secondary somatosensory cortex (5) · Posterior parietal cortex (7)   Occipital lobe   Superolateral Occipital pole of cerebrum · Lateral occipital gyrus (18, 19) · Lunate sulcus · Transverse occipital sulcus   Medial/inferior Primary visual cortex (17) · Cuneus · Lingual gyrus Calcarine fissure   Temporal lobe   Superolateral Transverse temporal gyrus/Primary auditory cortex (41, 42) · Superior temporal gyrus (38, 22/Wernicke's area) · Middle temporal gyrus (21) · Inferior temporal gyrus (20)   Superior temporal sulcus · Inferior temporal sulcus   Medial/inferior Fusiform gyrus (37) Medial temporal lobe ((27 · 28 · 34 · 35 · 36))   Inferior temporal sulcus   Interlobar sulci/fissures   Superolateral Central (frontal+parietal) · Lateral (frontal+parietal+temporal) · Parieto-occipital · Preoccipital notch   Medial/inferior Medial longitudinal · Cingulate (frontal+cingulate) · Collateral (temporal+occipital) · Callosal sulcus   Limbic lobe   Parahippocampal gyrus anterior (Entorhinal cortex, Perirhinal cortex) · Posterior parahippocampal gyrus · Prepyriform area   Cingulate cortex/gyrus Subgenual area (25) · Anterior cingulate (24, 32, 33) · Posterior cingulate (23, 31) Isthmus of cingulate gyrus: Retrosplenial cortex (26, 29, 30)   Hippocampal formation Hippocampal sulcus · Fimbria of hippocampus · Dentate gyrus   Other Supracallosal gyrus · Uncus   Insular lobe Long gyrus of insula · Short gyri of insula · Circular sulcus of insula   General Operculum · Poles of cerebral hemispheres   Some categorizations are approximations, and some Brodmann areas span gyri.