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*
Endothelium-derived relaxing factor
(EDRF)
is produced and released by the
endothelium that results in smooth
muscle relaxation.
THE NOBEL
laureates won their prize for
discovering that NO (Nitric Oxide) is a
potent relaxer of blood vessels. But
since this landmark finding, we have
learned much more about how NO
contributes to cardiovascular health. We
have also learned how to improve the
production of this lifesaving molecule
through nutrition and lifestyle changes.
Based on the work of many research
groups, including my own, we now know
that when someone has heart disease or
risk factors for heart disease, their
endothelium is impaired. When the
endothelium is not healthy, the vessel
constricts and, over time, the vessel
wall thickens. Blood cells are more
likely to stick to the vessel, and this
accumulation may lead to the formation
of a blood clot or the development of
atherosclerotic plaque
However, when the endothelium is
healthy, it releases NO, which relaxes
the blood vessels, prevents cells from
sticking to the vessel wall, and
prevents the vessel wall from
thickening.
A healthy endothelium is like Teflon, a
nonstick surface that enhances the flow
of blood. By contrast, an unhealthy
endothelium is like Velcro, with white
blood cells and platelets sticking to
it. Together, NO and its sister
molecule prostacyclin act together to
maintain the vessel in a relaxed state
and to prevent the development of blood
clots and plaque
What exactly does NO (Nitric Oxide) do
for your blood vessels?
NO opens blood vessels and keeps them
relaxed.
To keep your circulatory system as
healthy as possible, you will want your
blood vessels to be as relaxed and
pliable as
possible. NO is the
strongest natural relaxant of blood
vessels. By causing blood vessels to
open up, NO increases blood flow
through them. As a cardiologist I have
several vasodilating drugs that I can
administer to my patients. I use these
drugs to improve blood flow and to lower
blood pressure. But by ensuring that
your body makes NO on its own, you have
a natural vasodilator right in your own
body. Like nitroglycerin, NO acts on the
blood vessels immediately.
NO prevents
atherosclerosis. NO is a
natural substance that protects us from
hardening of the arteries. It does this
by preventing platelets (particles in
the blood that form blood clots) and
white blood cells from sticking to the
vessel
wall. NO also reduces the
production of free radicals, which can
cause your vessels to age rapidly
NO also suppresses the abnormal growth
of vascular muscle cells, which can
thicken the vessel. All of these
processes-the sticking of blood cells to
the vessel, the production of free
radicals, and abnormal cell
growth-contribute to atherosclerosis.
By halting these processes,
endothelium-made NO is your body's
strongest self-defense against heart
attack and stroke. NO can prevent
hardening of the arteries and even
reverse it. This process may take some
time and is one of the long-term
benefits of NO.
The last few years have been exciting
for me and for other scientists working
in this area of vascular medicine. We
have uncovered many secrets of the body
and the blood vessels. However, it is
even more gratifying for me to use these
secrets to enhance vessel health. I
believe that it is important for people
to learn how to enhance the eating power
within-and to benefit from the body's
natural defense against heart attack
and stroke.
Can NO help you? The answer is yes-by
helping to keep your vessels relaxed and
open and by preventing atherosclerosis.
It is never too late to learn about the
power of NO. I have seen people with
very unhealthy blood vessels become more
healthy. The endothelium can be
repaired. Atherosclerosis can be
reversed
When the lining of the blood vessels in
healthy cells don't stick, clots don't
form, arteries don't harden, and you
won't die of a heart attack or stroke.
The cardiovascular cure is a healthy
endothelium. It is certainly promising
news for all of us.
*
Endothelium-derived relaxing factor
(EDRF)
is produced and released by the
endothelium that results in smooth
muscle relaxation.
This Article was written by John P.
Cooke, M. D. PH. D. It is from his book
The Cardiovascular Cure, Page 12
and 13.
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